Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc.

Healthcare

NASDAQ:ALNY · NASDAQ Global Select

Market Cap $37.86B Beta 0.27 P/E (TTM) 65.3
$283.57 -2.01%

-$5.82 today

52W Low $281.77High $495.55

Vol 0.83M · Avg 1.11M

EPS (TTM)$4.34
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

39.8%

avg 8.6%

ROIC

13.7%

avg -24.7%

ROA

6.3%

avg -23.2%

Analysis

ROE is currently the strongest return metric at 39.8% versus its period average of 8.6%. 3 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Yvonne L. Greenstreet

Chief Executive Officer & Director$4.99M63$98,364.000.07%

Pushkal Garg

Executive VP & Chief Research & Development Officer$1.86M58$20,443.000.02%

Jeffrey V. Poulton

Chief Financial Officer & Executive Vice President$1.70M58$64,159.000.05%

Tolga Tanguler

Executive Vice President & Chief Commercial Officer$1.50M53$36,500.000.03%

Kevin Joseph Fitzgerald

Executive Vice President, Chief Scientific Officer and Head of Early Research & Early Development$1.23M58$20,870.000.02%

Bryan Andrew Supran

Chief Legal Officer$845,920.0056$14,565.000.01%

Phillip A. Sharp

Co-Founder, Member of the Scientific Advisory Board$52,930.0081$11,250.00<0.01%

Melissa McLaughlin

Chief Human Resources Officer$9,443.00<0.01%

Piyush Sharma

Chief Ethics & Compliance Officer

Timothy J. Maines

Chief Technical Operations & Quality Officer

Christine Regan Akinc

Chief Corporate Communications Officer44

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

147

$20.50M

Net Sentiment

$20.50M

Net selling

Most Active

Garg Pushkal

37 transactions

DateInsiderTypeSharesPriceValue
Jun 1, 2026

PYOTT DAVID E I

Direct

Sell921$297.71$274,190.91
Jun 1, 2026

PYOTT DAVID E I

Direct

Sell1.2K$299.87$366,441.14
Jun 1, 2026

PYOTT DAVID E I

Direct

Sell1.2K$298.91$351,219.25
Jun 1, 2026

PYOTT DAVID E I

Direct

Sell17$302.65$5,145.05
Jun 1, 2026

PYOTT DAVID E I

Direct

Sell495$300.72$148,856.40
Apr 6, 2026

McLaughlin Melissa

Direct

Sell199$333.94$66,454.06
Apr 6, 2026

McLaughlin Melissa

Direct

Sell56$320.14$17,927.84
Apr 6, 2026

McLaughlin Melissa

Direct

Sell909$329.76$299,751.84
Apr 6, 2026

McLaughlin Melissa

Direct

Sell829$330.46$273,951.34
Apr 6, 2026

McLaughlin Melissa

Direct

Sell293$331.89$97,243.77

1–10 of 147

Analysis

Insiders reported 0 buys worth $0.00 and 147 sells worth $20.50M over the last 12 months. That adds up to net selling of $20.50M. Garg Pushkal was the most active insider with 37 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A6 analysts
RevenueN/AN/A-14.9%
+45.8% (15yr)10 analysts
Net IncomeN/AN/AN/A
N/A10 analysts
EBITN/AN/AN/A
N/A10 analysts

Analysis

Recent growth has been strongest in Revenue at -14.9% over three years. Forward estimates point to Revenue at +45.8% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages ALNY?

Alnylam Pharmaceuticals, Inc. (ALNY) lists 11 active executives. The top listed executive is Jeffrey V. Poulton, Chief Financial Officer & Executive Vice President.

Are ALNY insiders buying or selling?

Recent insider activity shows net buying of $8.36M.

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