Spruce Biosciences, Inc.

Spruce Biosciences, Inc.

SPRB·NASDAQ

$49.05

-0.22%
HealthcareBiotechnology

Spruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for adult patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction and clinical consequences in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in Daly City, California.

At a Glance

Live Snapshot
Market Cap$67.30M
EPS-50.8300
P/E Ratio-0.96
Earnings Date08/13/2026
-84.42%
Return on Invested Capital
-52%
3Y+34.0%
5Y+340.0%
10Y-82.0%
-91.65%
Return on Equity
-50%
3Y+36.0%
5Y+356.0%
10Y-266.0%
-73.49%
Return on Assets
-37%
3Y+36.0%
5Y+299.0%
10Y-64.0%
Spruce Biosciences, Inc.

Spruce Biosciences, Inc. Management Team

SPRB · NASDAQ
DJ

Dr. Javier Szwarcberg M.D., M.P.H.

Chief Executive Officer & Director

Compensation

$950,500

Born 1970(Age 56)
DK

Dr. Kirk Ways M.D., Ph.D.

Chief Medical Officer & Director

Compensation

$51,750

Born 1952(Age 74)
MM

Mr. Michael G. Grey

Executive Chairman

Compensation

$70,000

Born 1953(Age 73)
male
MS

Mr. Samir M. Gharib CPA, M.B.A.

President & Chief Financial Officer

Compensation

$680,025

Born 1982(Age 44)
male
sprb

Spruce Biosciences, Inc. Insider Positioning

SPRB · NASDAQ

During the last 12 months, insiders have purchased $25K worth of SPRB shares, with no selling activity reported.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

9-12 Months

Bought

210.0K

24.62K

Sold

0

0.00

Net Activity

+25K

+$25K

Top Buyers

1
WK

Ways Kirk

Director, Officer: Interim Chief Medical Officer

30.0K shares1 transactions

$4K

2
SDK

Spiegelman Daniel K

Director

30.0K shares1 transactions

$3K

3
SCV

Simpson Camilla V

Director

30.0K shares1 transactions

$3K

4
GMG

Grey Michael G

Director, Officer: Executive Chairman

30.0K shares1 transactions

$3K

5
BP

Barretto-Ko Percival

Director

30.0K shares1 transactions

$3K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $25K net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Insider Participation

High Buying

5 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

SPRB - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 09, 2026
April 09, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 28, 2025
June 09, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 05, 2024
May 22, 2024
2024
DEF 14A

DEF 14A 2023

N/A

April 05, 2023
May 25, 2023
2023
DEF 14A

DEF 14A 2022

N/A

April 07, 2022
May 25, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 02, 2021
May 20, 2021
2021
Showing 1 to 6 of 6 filings