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Palvella Therapeutics, Inc.

PVLAยทNASDAQ

$115.42

+10%
HealthcareBiotechnology

Palvella Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel therapies to treat patients serious and rare genetic skin diseases. Its lead product candidate is QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin) that is in Phase 3 clinical trial for the treatment of microcystic lymphatic malformations, as well as in Phase 2 clinical trial to treat cutaneous venous malformations. It also develops QTORIN rapamycin for the treatment of other mTOR-driven skin diseases. The company is based in Wayne, Pennsylvania.

At a Glance

Live Snapshot
Market Cap$1.37B
EPS-3.7100
P/E Ratio-31.11
Earnings Date08/13/2026
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Palvella Therapeutics, Inc. Street Expectations Map

PVLA ยท NASDAQ

Wall Street analysts project that PVLA stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 205.15, with estimates ranging from a low of 143.00 to a high of 255.00.

Lowest Target
143.00
23.90%
Consensus Target
205.15
77.74%
Highest Target
255.00
120.93%

The consensus 1-year price target stands at 205.15, with estimates ranging from a low of 143.00 to a high of 255.00.

Analyst Consensus Analysis

Upside Potential

+77.7%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

54.6% spread

Mixed analyst views. Wide target range suggests differing opinions on key value drivers, growth prospects, or risk factors.

Analyst Conviction

Low

Bearish or uncertain outlook. Limited upside or poor consensus suggests challenges ahead or fundamental concerns.

Market Sentiment Insight

High risk, high reward: Substantial upside potential exists, but wide analyst disagreement signals execution risk or unclear catalysts. Thorough due diligence essential before committing capital.

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Palvella Therapeutics, Inc. Forward Estimates of Revenue

PVLA ยท NASDAQ
Latest Revenue
0.00
FY 2025
Avg Estimate
26.67K
FY 2026
Estimate Range
8.88K - 55.98K
Analyst Spread

Forward Growth Analysis

Analyst Coverage10 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread177%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

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Palvella Therapeutics, Inc. Forward Estimates of Net Income

PVLA ยท NASDAQ
Latest Net Income
-41.72M
FY 2025
Avg Estimate
-57.35M
FY 2026
Estimate Range
-73.73M - -40.96M
Analyst Spread

Forward Growth Analysis

Projected Growth-37.5%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage10 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread57%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Palvella Therapeutics, Inc. Forward Estimates of EPS

PVLA ยท NASDAQ
Latest EPS
-3.71
FY 2025
Avg Estimate
$-5.55
FY 2026
Estimate Range
$-6.55 - $-3.64
Analyst Spread

Forward Growth Analysis

Projected Growth-49.6%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage12 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread52%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Palvella Therapeutics, Inc. Forward Estimates of EBIT

PVLA ยท NASDAQ
Latest EBIT
-35.90M
FY 2025
Avg Estimate
5.33K
FY 2026
Estimate Range
1.77K - 11.20K
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage10 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread177%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Palvella Therapeutics, Inc. Forward Estimates of EBITDA

PVLA ยท NASDAQ
Latest EBITDA
-35.90M
FY 2025
Avg Estimate
5.33K
FY 2026
Estimate Range
1.77K - 11.20K
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage10 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread177%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Palvella Therapeutics, Inc. Forward Estimates of SG&A Expense

PVLA ยท NASDAQ
Latest SG&A Expense
15.76M
FY 2025
Avg Estimate
22.20K
FY 2026
Estimate Range
7.39K - 46.61K
Analyst Spread

Forward Growth Analysis

Projected Growth-99.9%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage10 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread177%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Palvella Therapeutics, Inc. Insider Positioning

PVLA ยท NASDAQ

During the last 12 months, insiders have purchased $2.47M and sold $1.66M worth of PVLA shares, resulting in $807K of net buying activity.

3 Months

Bought

445

49.97K

Sold

7.1K

826.92K

Net Activity

-777K

-$777K

3-6 Months

Bought

6.4K

800.00K

Sold

7.9K

707.36K

Net Activity

+93K

+$93K

6-9 Months

Bought

0

0.00

Sold

1.5K

128.58K

Net Activity

-129K

-$129K

9-12 Months

Bought

61.8K

1.62M

Sold

0

0.00

Net Activity

+1.6M

+$1.62M

Top Buyers

1
JGM

Jenkins George M

Director

16.8K sharesโ€ข3 transactions

$874K

2
HEJ

Heron Elaine J

Director

14.8K sharesโ€ข2 transactions

$624K

3
KCP

Kiritsy Christopher P

Director

12.3K sharesโ€ข1 transactions

$324K

4
WTS

Wessel Tadd S.

Director

12.3K sharesโ€ข1 transactions

$324K

5
DTC

Davis Todd C

Director

12.3K sharesโ€ข1 transactions

$324K

Top Sellers

1
GK

Goin Kathleen

Officer: Chief Operating Officer

16.5K sharesโ€ข7 transactions

$1.66M

Insider Activity Analysis

Net Insider Sentiment

Bullish

Moderately bullish with $807K net buying. Insiders show cautious optimism through measured share purchases.

Buy/Sell Ratio

1.49:1

Positive buy/sell ratio. Buying exceeds or matches selling, indicating net positive insider sentiment.

Recent Trend (3 Months)

$777K

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Buying

5 insider buyers vs. 1 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Broad-based insider buying: When multiple insiders independently decide to purchase shares, it often reflects genuine confidence rather than coordinated optics. This pattern deserves attention, especially if buying followed a price decline.