Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc.

PTGXยทNASDAQ

$95.41

+1.5%
HealthcareBiotechnology

Protagonist Therapeutics, Inc., a biopharmaceutical company, discovers and develops peptide-based therapeutic drugs to address hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing rusfertide (PTG-300), an injectable hepcidin mimetic that is in Phase II clinical trials for the treatment of patients with polycythemia vera and hereditary hemochromatosis, as well as for the treatment of other blood disorders; PN-943, an oral, alpha-4-beta-7 integrin- specific antagonist peptide that is in Phase II clinical trials for treating inflammatory bowel disease (IBD); and PN-235, an orally delivered interleukin-23 receptor specific antagonist for the treatment of IBD and non-IBD indications. The company has a license and collaboration agreement with Janssen Biotech, Inc. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

At a Glance

Live Snapshot
Market Cap$6.14B
EPS-2.0500
P/E Ratio-46.54
Earnings Date07/30/2026
-25.23%
Return on Invested Capital
-171%
3Y-58.0%
5Y+12.0%
10Y-32.0%
-21.17%
Return on Equity
-152%
3Y-64.0%
5Y-11.0%
10Y-137.0%
-19.43%
Return on Assets
-153%
3Y-62.0%
5Y-5.0%
10Y-51.0%
Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. Management Team

PTGX ยท NASDAQ
DD

Dr. Dinesh V. Patel Ph.D.

Chief Executive Officer, President, Secretary & Director

Compensation

$1,366,917

Born 1957(Age 69)
DA

Dr. Arturo M. Molina FACP, M.D., M.S.

Chief Medical Officer

Compensation

$956,912

Born 1959(Age 67)
DA

Dr. Ashok Bhandari Ph.D.

EVice President & Chief Discovery Officer

Born 1964(Age 62)
MA

Mr. Asif Ali

Executive Vice President & Chief Financial Officer

Compensation

$805,042

Born 1974(Age 52)
male
MM

Mr. Mohammad Masjedizadeh Ph.D.

Executive Vice President & Chief Technology Officer

male
MM

Mr. Matthew M. Gosling J.D.

Executive Vice President & General Counsel

Born 1971(Age 55)
male
MM

Mr. Matthew M. Gosling J.D.

Executive Vice President and Chief Legal & Business Officer

Born 1971(Age 55)
male
MC

Mr. Carter J. King

Executive Vice President of Business Development

Born 1971(Age 55)
male
DS

Dr. Suneel K. Gupta Ph.D.

Executive Vice President of Clinical Development

Compensation

$896,847

Born 1958(Age 68)
DN

Dr. Newman Yeilding

Executive Vice President, Chief Scientific Officer

MC

Ms. Carena Spivey

Head of HR & Senior Vice President of Human Resources

female
MC

Ms. Carena Spivey

Senior Vice President & Chief Human Resources Officer

female
ptgx

Protagonist Therapeutics, Inc. Insider Positioning

PTGX ยท NASDAQ

During the last 12 months, insiders have sold $40.92M worth of PTGX shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

245.3K

24.90M

Net Activity

-24.9M

-$24.90M

3-6 Months

Bought

0

0.00

Sold

120.5K

10.02M

Net Activity

-10.0M

-$10.02M

6-9 Months

Bought

0

0.00

Sold

14.7K

1.19M

Net Activity

-1.2M

-$1.19M

9-12 Months

Bought

0

0.00

Sold

86.9K

4.81M

Net Activity

-4.8M

-$4.81M

Top Buyers

No buying activity

Top Sellers

1
PDVPD

Patel Dinesh V Ph D

Director, Officer: President And Ceo

256.9K sharesโ€ข9 transactions

$21.85M

2
GB

Giraudo Bryan

Director

41.1K sharesโ€ข2 transactions

$4.12M

3
WWD

Waddill William D.

Director

45.0K sharesโ€ข5 transactions

$3.77M

4
MAM

Molina Arturo Md

Officer: Chief Medical Officer

47.2K sharesโ€ข5 transactions

$3.71M

5
AA

Ali Asif

Officer: Chief Financial Officer

35.1K sharesโ€ข3 transactions

$3.47M

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $40.92M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$24.90M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

PTGX - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 28, 2026
June 17, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 29, 2025
June 20, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 26, 2024
June 20, 2024
2024
DEF 14A

DEF 14A 2023

N/A

April 12, 2023
May 25, 2023
2023
DEF 14A

DEF 14A 2022

N/A

April 13, 2022
May 26, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 14, 2021
May 27, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 16, 2020
May 28, 2020
2020
DEF 14A

DEF 14A 2019

N/A

April 26, 2019
June 07, 2019
2019
DEF 14A

DEF 14A 2018

N/A

April 18, 2018
May 29, 2018
2018
DEF 14A

DEF 14A 2017

N/A

April 24, 2017
May 25, 2017
2017
Showing 1 to 10 of 10 filings