PepGen Inc.

PepGen Inc.

PEPG·NASDAQ

$1.46

+3.0%
HealthcareBiotechnology

PepGen Inc., a clinical-stage biotechnology company, focuses on the development of oligonucleotide therapeutics for use in the treatment of severe neuromuscular and neurologic diseases. The company's lead product candidate is PGN-EDO51, an EDO peptide in Phase I clinical trials to treat individuals with Duchenne muscular dystrophy (DMD). It is also developing PGN-EDODM1, an EDO peptide-conjugated PMO for the treatment of myotonic dystrophy type 1, as well as EDO therapeutic candidates, such as PGN-EDO53, PGN-EDO45, and PGN-EDO44 for the treatment of DMD. The company was founded in 2018 and is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$101.28M
EPS-2.1200
P/E Ratio-0.69
Earnings Date08/06/2026
-56.93%
Return on Invested Capital
-19%
3Y+70.0%
5Y+197.0%
10Y+63.0%
-60.81%
Return on Equity
-20%
3Y+58.0%
5Y+215.0%
10Y+75.0%
-51.55%
Return on Assets
-14%
3Y+62.0%
5Y+190.0%
10Y+61.0%
PepGen Inc.

PepGen Inc. Management Team

PEPG · NASDAQ
MN

Mr. Noel P. Donnelly M.B.A.

Chief Financial Officer

Compensation

$633,705

Born 1970(Age 56)
male
ME

Ms. Emiko Bryant

Chief of Staff, HR & Operations

female
DP

Dr. Paul D. Streck M.B.A., M.D.

Executive Vice President and Head of Research & Development

Compensation

$332,733

Born 1964(Age 62)
DM

Dr. Michael Gait Ph.D.

Founder & Scientific Advisory Board Member

MM

Ms. Mary Beth DeLena J.D.

General Counsel & Secretary

Born 1968(Age 58)
female
DJ

Dr. James G. McArthur Ph.D.

President, Chief Executive Officer, Treasurer, Secretary & Director

Compensation

$850,668

Born 1962(Age 64)
DH

Dr. Hayley Parker Ph.D.

Senior Vice President of Global Regulatory Affairs

DA

Dr. Afsaneh Mohebbi Ph.D.

Senior Vice President of Portfolio and Program Management

MK

Mr. Kyle Breidenstine CPA, M.B.A.

Vice President of Finance & Controller

male
pepg

PepGen Inc. Insider Positioning

PEPG · NASDAQ

During the last 12 months, insiders have purchased $30.78M and sold $13K worth of PEPG shares, resulting in $30.77M of net buying activity.

3 Months

Bought

0

0.00

Sold

1.2K

1.74K

Net Activity

-2K

-$2K

3-6 Months

Bought

0

0.00

Sold

1.8K

11.41K

Net Activity

-11K

-$11K

6-9 Months

Bought

9.6M

30.64M

Sold

0

0.00

Net Activity

+30.6M

+$30.64M

9-12 Months

Bought

96.0K

144.96K

Sold

0

0.00

Net Activity

+145K

+$145K

Top Buyers

1
RCML

Ra Capital Management, L.P.

Director, 10 Percent Owner:

9.4M shares2 transactions

$30.02M

2
OSEP

Oxford Science Enterprises Plc

Other: Former 10% Owner

200.0K shares1 transactions

$640K

3
DHJ

Dable Habib J

Director

16.0K shares1 transactions

$24K

4
RJ

Resnick Joshua

Director

16.0K shares1 transactions

$24K

5
MH

Mayer Howard

Director

16.0K shares1 transactions

$24K

Top Sellers

1
SP

Streck Paul

Officer: Evp, Head Of R&D

1.8K shares1 transactions

$11K

2
KK

Kasraian Kasra

Officer: Chief Technical Officer

1.2K shares1 transactions

$2K

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $30.77M net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

2340.71:1

Exceptional buy/sell ratio. Buying dramatically outweighs selling—one of the strongest possible insider signals.

Recent Trend (3 Months)

$2K

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Buying

5 insider buyers vs. 2 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

PEPG - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 28, 2026
June 18, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 25, 2025
June 04, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 26, 2024
June 20, 2024
2024
DEF 14A

DEF 14A 2023

N/A

April 28, 2023
June 22, 2023
2023
Showing 1 to 4 of 4 filings