Gain Therapeutics, Inc.

Gain Therapeutics, Inc.

GANX·NASDAQ

$1.88

+4.7%
HealthcareBiotechnology

Gain Therapeutics, Inc., a biotechnology company, engages in developing various therapies to treat diseases caused by protein misfolding. It focuses on rare genetic diseases and neurological disorders. The company uses its Site-Directed Enzyme Enhancement Therapy platform to discover allosteric sites on misfolded proteins and identify proprietary small molecules that bind these sites, restore protein folding, and treat disease. It is developing structurally targeted allosteric regulator candidates to treat various diseases, including Morquio B, GM1 gangliosidosis (GM1), neuronopathic Gaucher disease, GBA1 Parkinson's, Krabbe, and Mucopolysaccharidosis type 1 diseases. The company was founded in 2017 and is based in Bethesda, Maryland.

At a Glance

Live Snapshot
Market Cap$79.98M
EPS-0.6100
P/E Ratio-3.07
Earnings Date08/06/2026
-95.04%
Return on Invested Capital
-60%
3Y+9.0%
5Y+109.0%
10Y-65.0%
-108.60%
Return on Equity
-61%
3Y+17.0%
5Y+88.0%
10Y-193.0%
-88.35%
Return on Assets
-48%
3Y+21.0%
5Y+137.0%
10Y-35.0%
Gain Therapeutics, Inc.

Gain Therapeutics, Inc. Management Team

GANX · NASDAQ
DK

Dr. Khalid Islam Ph.D.

Chairman & Founder

Compensation

$75,000

Born 1955(Age 71)
DJ

Dr. Jonas Hannestad M.D., Ph.D.

Chief Medical Officer

MG

Mr. Gene Mack M.B.A.

President, Chief Executive Officer & Director

Compensation

$535,091

male
MG

Mr. Gianluca Fuggetta

Senior Vice President of Finance & Principal Financial Officer

Compensation

$228,345

Born 1989(Age 37)
male
DJ

Dr. Joanne Taylor Ph.D.

Senior Vice President of Research

DT

Dr. Terenzio Ignoni Pharm.D.

Senior Vice President of Technical Operations

ganx

Gain Therapeutics, Inc. Insider Positioning

GANX · NASDAQ

During the last 12 months, insiders have purchased $188K worth of GANX shares, with no selling activity reported.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

9-12 Months

Bought

105.0K

187.95K

Sold

0

0.00

Net Activity

+188K

+$188K

Top Buyers

1
IK

Islam Khalid

Director

15.0K shares1 transactions

$27K

2
NC

Nicaise Claude

Director

15.0K shares1 transactions

$27K

3
RJS

Riley Jeffrey Scott

Director

15.0K shares1 transactions

$27K

4
REI

Richman Eric I

Director

15.0K shares1 transactions

$27K

5
HHP

Hasler Hans Peter

Director

15.0K shares1 transactions

$27K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $188K net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Insider Participation

High Buying

5 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

GANX - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 28, 2026
June 24, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 29, 2025
June 24, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 26, 2024
June 24, 2024
2024
DEF 14A

DEF 14A 2023

N/A

April 28, 2023
June 23, 2023
2023
DEF 14A

DEF 14A 2022

N/A

May 13, 2022
June 16, 2022
2022
Showing 1 to 5 of 5 filings