Apogee Therapeutics, Inc.

Apogee Therapeutics, Inc.

APGE·NASDAQ

$84.19

+3.0%
HealthcareBiotechnology

Apogee Therapeutics, Inc., through its subsidiary, operates as a biotechnology company that develops biologics for the treatment of atopic dermatitis (AD), chronic obstructive pulmonary disease (COPD), and related inflammatory and immunology indications. The company primarily develops APG777, a subcutaneous (SQ) extended half-life monoclonal antibody (mAb) for AD; and APG808, an SQ extended half-life mAb for COPD. Its earlier-stage programs include APG990, an SQ extended half-life mAb for the treatment of AD; and APG222, an extended half-life SQ antibodies for AD. The company was founded in 2022 and is based in Waltham, Massachusetts.

At a Glance

Live Snapshot
Market Cap$5.21B
EPS-4.2200
P/E Ratio-19.95
Earnings Date08/10/2026
-31.29%
Return on Invested Capital
5%
3Y+45.0%
5Y+45.0%
10Y+45.0%
-28.30%
Return on Equity
11%
3Y+1.0%
5Y+1.0%
10Y+1.0%
-27.30%
Return on Assets
13%
3Y+4.0%
5Y+4.0%
10Y+4.0%
Apogee Therapeutics, Inc.

Apogee Therapeutics, Inc. Management Team

APGE · NASDAQ
DR

Dr. Rebecca Dabora Ph.D.

Chief Development Officer

Born 1959(Age 67)
DM

Dr. Michael Thomas Henderson M.D.

Chief Executive Officer & Director

Compensation

$1,207,238

Born 1990(Age 36)
MJ

Ms. Jane Pritchett V. Henderson

Chief Financial Officer

Compensation

$879,375

Born 1966(Age 60)
female
MM

Mr. Matthew Batters J.D.

Chief Legal Officer & Corporate Secretary

Born 1976(Age 50)
male
DC

Dr. Carl Linden Dambkowski M.D.

Chief Medical Officer

Compensation

$879,375

Born 1985(Age 41)
ME

Ms. Emily Cox

SVice President & Head of People

female
DD

Dr. Drew Badger Ph.D.

Senior Vice President and Head of Regulatory Affairs & Toxicology

MW

Ms. Wendy Aspden-Curran

Senior Vice President of Clinical Operations

female
MM

Ms. Monica Forbes

Senior Vice President of Finance

Born 1976(Age 50)
female
MN

Ms. Noel Kurdi

Vice President of Investor Relations

female
apge

Apogee Therapeutics, Inc. Insider Positioning

APGE · NASDAQ

During the last 12 months, insiders have sold $145.12M worth of APGE shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

56.0K

4.57M

Net Activity

-4.6M

-$4.57M

3-6 Months

Bought

0

0.00

Sold

1.8M

135.82M

Net Activity

-135.8M

-$135.82M

6-9 Months

Bought

0

0.00

Sold

62.8K

4.47M

Net Activity

-4.5M

-$4.47M

9-12 Months

Bought

0

0.00

Sold

6.4K

245.50K

Net Activity

-245K

-$245K

Top Buyers

No buying activity

Top Sellers

1
FFML

Fairmount Funds Management Llc

Director

1.8M shares1 transactions

$133.53M

2
HMT

Henderson Michael Thomas

Director, Officer: Chief Executive Officer

107.3K shares8 transactions

$8.17M

3
DC

Dambkowski Carl

Officer: Chief Medical Officer

38.1K shares12 transactions

$2.46M

4
HJ

Henderson Jane

Officer: Chief Financial Officer

12.6K shares9 transactions

$964K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $145.12M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$4.57M

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

4 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

APGE - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 24, 2026
June 09, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 29, 2025
June 17, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 24, 2024
June 05, 2024
2024
Showing 1 to 3 of 3 filings