Taysha Gene Therapies, Inc.

Taysha Gene Therapies, Inc.

TSHAยทNASDAQ

$5.79

+1.7%
HealthcareBiotechnology

Taysha Gene Therapies, Inc., a gene therapy company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of monogenic diseases of the central nervous system. It primarily develops TSHA-120 for the treatment of giant axonal neuropathy; TSHA-102 for the treatment of Rett syndrome; TSHA-121 for the treatment of CLN1 disease; TSHA-118 for the treatment of CLN1 disease; TSHA-105 foe the treatment of for SLC13A5 Deficiency; and TSHA-101 for the treatment of GM2 gangliosidosis. Taysha Gene Therapies, Inc. has a strategic partnership with The University of Texas Southwestern Medical Center to develop and commercialize transformative gene therapy treatments. The company was incorporated in 2019 and is based in Dallas, Texas.

At a Glance

Live Snapshot
Market Cap$1.45B
EPS-0.3400
P/E Ratio-17.01
Earnings Date08/11/2026
3Y+291.0%
5Y-
10Y-
3Y-34.0%
5Y+153.0%
10Y+9675.0%
3Y+5.0%
5Y+203.0%
10Y-69056.0%
Taysha Gene Therapies, Inc.

Taysha Gene Therapies, Inc. Profit Bridge

TSHA ยท NASDAQ
Revenue9.77M
Cost of Goods Sold (1.15M)
Gross Profit8.63M
Operating Expenses (119.13M)
Operating Income-110.50M
Interest Expense (63.00K)
Other Income/Expense1.50M
Pretax Income-109.00M
Income Tax (0.00)
Net Income-109.00M
Net Income
-109.00M

Profitability Analysis

Gross Margin

88.3%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-1130.6%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-1115.3%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Taysha Gene Therapies, Inc. Income Statement

TSHA โ€ข NASDAQ

Taysha Gene Therapies, Inc. Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019
REVENUE
9.8M
8.3M
15.5M
2.5M
0.0
0.0
0.0
GROSS PROFIT
(1.1M)
(0.0)
(0.0)
(2.5M)
(0.0)
(9K)
(0.0)
8.6M
8.3M
15.5M
15K
0.0
-9K
0.0
OPERATING INCOME
(119.1M)
(99.8M)
(87.9M)
(126M)
(173.3M)
(43M)
(1.1M)
(32.7M)
(29M)
(30M)
(34.9M)
(41.3M)
(11.1M)
(128K)
(86.4M)
(66M)
(56.8M)
(91.2M)
(131.9M)
(31.9M)
(987K)
-110.5M
-91.5M
-72.4M
-126M
-173.3M
-43M
-1.1M
PRE-TAX INCOME
(63K)
(102K)
(5M)
(3.8M)
(1.4M)
(28K)
(0.0)
9.2M
6.8M
-1.4M
-3.5M
-1.3M
21K
0.0
(0.0)
(4.8M)
(1.1M)
(0.0)
(0.0)
(0.0)
(0.0)
1.5M
2.2M
-39.1M
-40M
-1.3M
-17M
0.0
-109M
-89.3M
-111.6M
-166M
-174.5M
-60M
-1.1M
NET INCOME
-109M
-89.3M
-111.6M
-166M
-174.5M
-43M
-1.1M

SEC Filings

TSHA - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
8-K

8-K 2026

N/A

June 02, 2026
June 01, 2026
2026
10-Q

10-Q 2026 Q1

Q1

May 06, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 06, 2026
May 06, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 22, 2026
June 01, 2026
2026
10-K

10-K 2025 FY

FY

March 19, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

March 19, 2026
March 19, 2026
2026
8-K

8-K 2025

N/A

November 04, 2025
November 04, 2025
2025
10-Q

10-Q 2025 Q3

Q3

November 04, 2025
September 30, 2025
2025
8-K

8-K 2025

N/A

October 16, 2025
October 16, 2025
2025
8-K

8-K 2025

N/A

October 09, 2025
October 09, 2025
2025
Showing 1 to 10 of 126 filings